The Power of Three ("GGG")
Unlike current drugs that target one or two pathways, Retatrutide hits three. The addition of Glucagon is the key differentiator, turning the body's metabolism into a furnace.
GLP-1
The Appetite Controller
Found in Wegovy & Ozempic.
- ● Increases Satiety
- ● Slows Digestion
- ● Stimulates Insulin
GIP
The Synergist
Found in Mounjaro (with GLP-1).
- ● Improves Tolerability
- ● Potentiates Insulin
- ● Fat Metabolism
Glucagon
The Metabolic Furnace
The Retatrutide Advantage.
- ● Burns Energy (REE)
- ● Clears Liver Fat
- ● Protects Kidneys
Unprecedented Weight Loss
Phase 2 Clinical Trial Results (NEJM 2023)
Weight Loss Over Time (48 Weeks)
Participants on the 12mg dose saw rapid, sustained weight loss, not yet plateauing at week 48.
The Competitive Landscape
Comparing maximum reported efficacy across separate pivotal trials. Retatrutide approaches bariatric surgery levels.
Liver Fat Obliteration
For patients with Non-Alcoholic Fatty Liver Disease (NAFLD), Retatrutide was remarkably effective.
Mean Relative Reduction
Safety & Tolerability
Side effects are largely gastrointestinal and dose-dependent. Note the unique cardiac signal (heart rate increase) being monitored.